01 - Heat a large skillet over medium-high heat. Add the ground beef, season with salt, black pepper, garlic powder, and onion powder. Cook, breaking the meat apart with a wooden spoon, until fully browned and no pink remains, about 6 to 8 minutes. Drain excess fat if desired.
02 - While the beef cooks, divide the chopped romaine lettuce among 4 serving bowls. Arrange cherry tomatoes, diced red onion, sliced pickles, and shredded cheddar cheese evenly over each bed of lettuce.
03 - In a small mixing bowl, whisk together the mayonnaise, ketchup, yellow mustard, sweet relish, smoked paprika, and white vinegar until smooth and well combined. Taste and adjust seasoning as needed.
04 - Spoon the cooked ground beef evenly over the prepared salad bowls, dividing it into four equal portions.
05 - Drizzle the burger sauce generously over each bowl. Add any desired optional toppings such as crumbled bacon, sliced avocado, jalapeño slices, or sesame seeds. Serve immediately.