01 - Whisk buttermilk with salt, garlic powder, onion powder, cayenne, and black pepper in a large bowl. Submerge chicken pieces completely in the marinade. Cover bowl and refrigerate minimum 2 hours, preferably overnight for optimal flavor penetration.
02 - Combine flour, paprika, salt, black pepper, cayenne, and baking powder in a separate bowl. Whisk thoroughly to distribute spices evenly throughout the flour mixture.
03 - Remove chicken from marinade, allowing excess liquid to drip off. Press each piece firmly into flour mixture, ensuring thick, even coating on all sides. Arrange coated pieces on wire rack and rest for 10 minutes to help coating adhere.
04 - Pour vegetable oil into deep fryer or heavy-bottomed pot. Heat to 350°F, maintaining temperature throughout cooking process.
05 - Carefully lower chicken pieces into hot oil in small batches, avoiding overcrowding. Fry 12-15 minutes, turning occasionally, until golden brown and crisp. Internal temperature must reach 165°F for safe consumption.
06 - Transfer fried chicken to wire rack or paper towels to drain excess oil. Let rest 5 minutes before serving to allow juices to redistribute.